One of the early, non-financial uses of blockchain technologies around which several startups have developed was to help manage, monetize, and make the sharing of genomic data more private. Because deidentified genomic data are excluded from HIPAA and many other regulatory contexts worldwide—and is already a widely traded commodity for science valued in the hundreds of millions over the past decade—genomic blockchains proved a promising entry point for using the benefits of blockchains for dissemination and remuneration of data. Several models (...) have been tried, and most have touted their abilities to make users the “owners” of the genomic data in ways in which current models fail. This paper will explore the various existing and potential models for genomic blockchains, review some shortcomings and unmet needs, and explain why no technical solution alone will fulfill the promise of genomic data ownership without regulation. (shrink)

The universally recognized backbone of molecular biology describes the flow of genetic information from deoxyribonucleic acid (DNA) to ribonucleic acid (RNA) to protein or gene product, that is, DNA is transcribed into another nucleic acid (RNA), which is single stranded, next some types of RNA are in turn translated into proteins. Translation of nucleic acids to proteins is literally a translation from the genomic language to the metabolic language. Codons formed of a sequence of three nucleic acids summon a specific (...) amino acid. Translation from codons to proteins, that is, protein synthesis, takes place by specialized machinery comprising mRNA, ribosomes, and free amino acids. Inferring the structure of DNA opened the door for tremendous advances in understanding the role of genes in creating life, directing replication, and ongoing metabolic processes responsible for maintaining life at both the cellular and organism level. (shrink)

RESUMEN La medicina tradicional herbolaria desde su evolución hasta la contemporaneidad ha sido objeto de uso para la medicina convencional. Por eso el objetivo del trabajo es describir el comportamiento de la medicina tradicional herbolaria en los sistemas de salud convencionales. Se realizó la búsqueda y análisis documental de numerosas fuentes sobre la temática pertenecientes a las bases de datos SciELO Cuba, SciELO Regional, Science Direct, Clinical Key, Cumed, Lilacslo. Se concluye que la actualidad social registra manifestaciones alentadoras en el (...) campo de la aceptación de la herbolaria como medicina complementaria por el equipo de salud y un renovado interés en el ámbito mundial por estudiar los efectos que tienen las plantas sobre la salud. ABSTRACT The traditional herbalist medicine from its evolution to the contemporaneity has been an object use for the conventional medicine. That's why the objective of the work is to describe the behavior of the traditional herbalist medicine in the conventional health systems. A search and documentary analysis of numerous sources on the subject-matter belonging to the databases SciELO Cuba, SciELO Regional, Science Direct, Clinical Key, Cumed, Lilacslo was carried out. It is concluded that the social actuality registers encouraging declarations in the field of the acceptance of the herbalist as complementary medicine for the team of health and a renewed interest in the world ambience to study the effects that have the plants on the health. (shrink)

Despite the diverse legal approaches towards surrogacy in Europe, there are common socio-legal arguments attempting to legitimise it amongst the European Union member states. Regardless of the prevailing regulation in each country, surrogacy in general is confronted with common criticisms and faces similar obstacles. For instance, the operative definition of altruism is put under question in countries where altruistic surrogacy is permitted. Surrogacy is also considered an attack on a woman’s dignity and a risk to children’s welfare. Behind such claims, (...) however, rests the common yet unsubstantiated belief in a natural maternal instinct. Furthermore, a clear misunderstanding about the bonding theory still persists. Common debates around surrogacy in Europe show us that, beyond the national margin of appreciation, surrogacy challenges basic definitions of motherhood, filiation and family. These challenges are deeply permeated by gender stereotypes which partially explain the national similarities among the legal diversities. (shrink)

Climate change assessments rely upon scenarios of socioeconomic developments to conceptualize alternative outcomes for global greenhouse gas emissions. These are used in conjunction with climate models to make projections of future climate. Specifically, the estimations of greenhouse gas emissions based on socioeconomic scenarios constrain climate models in their outcomes of temperatures, precipitation, etc. Traditionally, the fundamental logic of the socioeconomic scenarios—that is, the logic that makes them plausible—is developed and prioritized using methods that are very subjective. This introduces a fundamental (...) challenge for climate change assessment: The veracity of projections of future climate currently rests on subjective ground. We elaborate on these subjective aspects of scenarios in climate change research. We then consider an alternative method for developing scenarios, a systems dynamics approach called ‘Cross-Impact Balance’ (CIB) analysis. We discuss notions of ‘objective’ and ‘objectivity’ as criteria for distinguishing appropriate scenario methods for climate change research. We distinguish seven distinct meanings of ‘objective,’ and demonstrate that CIB analysis is more objective than traditional subjective approaches. However, we also consider criticisms concerning which of the seven meanings of ‘objective’ are appropriate for scenario work. Finally, we arrive at conclusions regarding which meanings of ‘objective’ and ‘objectivity’ are relevant for climate change research. Because scientific assessments uncover knowledge relevant to the responses of a real, independently existing climate system, this requires scenario methodologies employed in such studies to also uphold the seven meanings of ‘objective’ and ‘objectivity.’. (shrink)

Prudential hedonism has been beset by many objections, the strength and number of which have led most modern philosophers to believe that it is implausible. One objection in particular, however, is nearly always cited when a philosopher wants to argue that prudential hedonism is implausible—the experience machine objection to hedonism. This paper examines this objection in detail. First, the deductive and abductive versions of the experience machine objection to hedonism are explained. Following this, the contemporary responses to each version of (...) the argument are assessed and the deductive version is argued to be relatively ineffective compared to the abductive version. Then, a taxonomy of the contemporary critical responses to the abductive version is created. Consideration of these responses shows that the abductive version of the objection is fairly powerful, but also that one type of response seems promising against it. This response argues that experience machine thought experiments seem to elicit judgments that are either too biased to be used as evidence for the objection or not obviously in favour of reality. It is argued that only this type of refutation seems likely to convince proponents of the abductive version that the objection is much weaker than they believe it to be. Finally, it is suggested that more evidence is required before anything definitive can be said on the matter. (shrink)

Expondremos el camino de interiorización a través del cual el hombre persigue su autognosis. Respetando la dualidad entre método y tema que caracteriza a la actividad intelectual, y la distinción entre esencia y acto de ser que caracteriza a las criaturas, ese camino hacia la autognosis se abre finalmente en busca de la réplica de que la persona humana carece. Se dibuja así el acceso antropológico a Dios, tal y como Polo lo ha propuesto. Desde la persona se vislumbra que (...) la identidad originaria del ser tiene también intimidad personal. (shrink)

El objetivo del trabajo fue fundamentar las bases teóricas que sustentan la importancia del trabajo independiente en el proceso de enseñanza aprendizaje en la Educación Médica Superior, así como aspectos relativos a su concepción, requerimientos y formas de aplicación. Se realizó un estudio bibliográfico acerca del tema y se llegó a las siguientes conclusiones: el trabajo independiente es un medio de organizar metodológicamente la actividad cognoscitiva independiente de los estudiantes que se expresa a través de un conjunto de tareas y (...) puede utilizarse durante la actividad docente y fuera de ella, así como en cualquiera de las formas de organización de que se trate. Es imprescindible que se tengan en cuenta al organizar el trabajo independiente las etapas de la actividad humana: planificación, orientación, ejecución y control. El trabajo independiente es un factor importante para estimular la independencia de los futuros profesionales de las Ciencias Médicas por lo que su perfeccionamiento exige al profesor una alta profesionalización de sus acciones. The objective of the work was to stablish the theorical bases that sustain the importance of the independent work in the teaching learning process in the medical education, as well as, relative aspects to its conception, requirements and application forms. A bibliographical study about the topic was carried out reaching the following conclusions the independent work is a way of organizing methologically the independent cognitive activity of the students that is expressed through out a group of tasks and it can be used during the teaching - learning in and out of the classroom; as well as in any of the forms of teaching organization. It is indispensable when organizing the independent work of the students to keep in mind the different stages of the human activity planning, orientation, execution and control. The independent work is an important factor to stimulate the independent of the future professionals of the medical sciences that is why its improvement demands a higher professionalism of its actions. (shrink)

El objetivo del presente trabajo es poner en diálogo la filosofía poliana del límite mental con el criticismo de Kant. Mantengo que por comenzar desde el hecho de que ellos toman el mismo método como tema, ambas posiciones teóricas están interconectadas. La limitación del conocimiento, el problema de su fundamentación, y la antropología que responde a ambas cuestiones será objeto de estudio del presente artículo.

Axiological foundations of free speach. Belandria, Margarita y González R., Javier Voluntad, ausencias, y normas: el sustrato histórico del positivismo en el derecho. Will, absences and norms: the historical background of positivism in law. Carpintero Benítez, Francisco Nominalismo jurídico, escolástica española y tradición republicana. Juridical nominalism, spanish scholasticism and republican tradition. Casanova Guerra, Carlos El primer principio de la razón práctica en la teoría de la ley natural de John Finnis. The first principle of practical reason in John Finnis´s natural (...) law theory. Hocevar G., Mayda G. El derecho a una educación integral de calidad, ¿utopía o posibilidad?. The right to an integral education of quality: utopia or possibility?. López de Cordero, Mery La muerte de la imagen. The death of the image. Peña, Edilio Karl Jaspers: autorreflexión y "existenzerhellung". Karl jaspers: self-reflection and "existenzerhellung". Portuondo Pajón, Gladys L. Derechos humanos y positivismo moderado. Human rights and temperated positivism. Ramos Pascua, José Antonio De la libertad y sus apariencias. On liberty and its appearances. Ramis Muscato, Pompeyo Pensamiento y vida: la "guía" zambraniana. Thought and life: zambrano's "guide" Rivara Kamaji, Greta Interdisciplinares Las mujeres en la ciencia de la salud. Women in the health sciences. Alcaraz Ariza, María Ángeles Cultura arquitectónica y crisis de la contemporaneidad. Architectural culture and crisis of the contemporary. Arellano Spinetti, Leonardo Recensiones Homenaje al filósofo venezolano Alberto Rosales. Walton, Roberto Informaciones Índice acumulado. (shrink)

En este artículo nos proponemos mostrar el lugar que ocupa el descubrimiento de los campos de trabajo forzado en la concepción sartriana de la política. Trataremos asimismo de mostrar que su concepción del poder impide captar la esencia totalitaria del régimen comunista que se estableció en la URSS a partir de 1923. Trataremos también de mostrar lo que dicha concepción debe a las discusiones con Maurice Merleau-Ponty y con Claude Lefort.

El trabajo ensaya un análisis sobre los perfiles subjetivos en la política dentro del esquema comunicacional vigente. El mundo global, la conectividad y las imágenes son elementos que invitan a atender como la palabra y la información funcionan en la actualidad. Esta revisión toma aportes de Sartori, Serres y Rancière, entre otros. Luego se discute el lugar de lo letrado como dispositivo de articulación de la comunidad. Para ello se examinan las tesis de Ángel Rama: el primado de la letra (...) implica un orden social con un impacto severo en la institucionalidad política. Posteriormente, se incorpora la noción de poslexia sugerida por Mark Fisher, quien afirma el carácter “iletrado” de la actualidad. Se construye así un diálogo en el que se profundizan algunas de las perspectivas implicadas. Finalmente, se sugieren algunas interrogantes sus efectos en la subjetividad política. Estas preguntas acuden a los aportes de Virno, Castillo y Ferraris, entre otros. (shrink)

Reseña del tratado anticristiano elaborado por el apóstata portugués Christovão Ferreira a partir de la edición anotada y prologada por Bernat Castany Prado.

The two authors of this paper have diametrically opposed views of the prevalence and strength of adaptation in nature. Hendry believes that adaptation can be seen almost everywhere and that evidence for it is overwhelming and ubiquitous. Gonzalez believes that adaptation is uncommon and that evidence for it is ambiguous at best. Neither author is certifiable to the knowledge of the other, leaving each to wonder where the other has his head buried. Extensive argument has revealed that each author (...) thinks his own view is amply supported by both theory and empirical evidence. Further reflection has revealed that the differences in opinion may start with the different disciplines in which we work: evolutionary ecology for Hendry and community ecology for Gonzalez. In the present paper, we each present devastating evidence supporting our own position and thus refuting that of the other. We then identify the critical differences that led to such opposing views. We close by combining our two perspectives into a common framework based on the adaptive landscape, and thereby suggest means by which to assess the prevalence and strength of adaptation. (shrink)

An increasing number of academic papers, newspaper articles, and other media representations from all over the world recently bring climate change’s impact on mental health into focus. Commonly summarized under the terms of climate or ecological emotions, these reports talk about distress, anxiety, trauma, grief, or depression in relation to environmental decline and anticipated climate crisis. While the majority of psychology and mental health literature thus far presents preliminary conceptual analysis and calls for empirical research, some explanations of ecological emotions (...) are already offered. They mainly draw from psychoanalysis and depth existential and humanistic psychology, as well as social psychology and address the relationship between ecological emotions and individual engagement in climate action. While these studies suggest building on individual resilience if concerned by ecological emotions, we argue that this only addresses their acute symptoms and not the social causes. Based upon our literature research, we show that in an individualistic society such as the liberal ones, feelings of individual responsibility are fostered, and this also applies to climate activism. (shrink)

El presente artículo tiene tres partes. La primera se centra en la santidad de Dios desde los textos bíblicos, siendo esta fuente de toda otra santidad, la cual se manifiesta en su belleza, su verdad y su bondad. La segunda desarrolla la invitación divina al hombre de vivir esta santidad en el proyecto original de la creación, así como la pobre respuesta del ser humano. La tercera mira al futuro en el que Dios ha prometido llevar a cabo la santificación (...) de los hombres. (shrink)

The study of agriculture in ancient societies is of vital importance for the understanding of their ecological basis. This article discusses data gathered from Alonso de Molina's dictionary, published in Mexico City in 1571. Molina's information on soil, rain, plants, technology, and human labor applied to agricultural activities gives a picture of the complexity of the several native agricultural systems practiced at that time. Since the Sixteenth Century, native agriculture was impacted by the introduction of new plants, animals, agricultural equipment, (...) and techniques from the Old World. A combination of the two agricultural models conform a new Mexican model of agriculture along the Colonial times. The knowledge of Sixteenth Century agricultural systems is fundamental for the understanding of the history and the conformation of contemporary agro-ecosystems. Recent studies on ecology and social anthropology agree on the necessity to take into account historical data for the discussion of ecological sustainability. (shrink)

A intenção deste texto foi refletir sobre como o trato com a dança pode configurar em relação pedagógica que incide sobre formas de pensar e fazer, para além do objetivo técnico inerente a esta arte. Aspectos da história da dança ajudam a identificar formas de pedagogias que sinalizam determinados modos de formação. A perspectiva da experiência estética baliza as discussões acerca da dança enquanto prática artística e educativa, portanto formativa, indicando que nela há a possibilidade de ampliar nossa compreensão sobre (...) nós mesmos e sobre o mundo. Já a improvisação em dança foi discutida como potencial revelador do sujeito que oportuniza descobertas, encontros entre o sujeito e suas formas de dançar e de se expressar. A partir desses entendimentos, concluímos que as relações pedagógicas, travadas no processo de ensinar e aprender dança, devem ter por princípios o impulso e o encorajamento, para que o sujeito construa novas formas de movimentos e de diálogos, intrínsecos ao processo de improvisação em dança e à própria vida. (shrink)

L’article interroge, à travers une vignette clinique, le désir d’enfant et l’infertilité secondaire en étant à l’écoute des enjeux inconscients et des représentations socioculturelles gabonaises. Il repère comment le recours à l’ amp n’exclut pas l’adhésion aux croyances traditionnelles de la malédiction. La recherche s’appuie sur une méthodologie qualitative et intègre la libre réalisation de l’arbre généalogique. L’utilisation de la médiation projective permet d’investiguer les liens familiaux, conjugaux et la place fantasmatique de l’enfant dans l’espace généalogique. L’analyse souligne, sur le (...) plan intrapsychique, une conflictualité œdipienne non résolue. Elle pointe le passage obligé par la maternité pour accéder à un statut social valorisé soutien de l’identité féminine. (shrink)

Fundamento: El currículo de estudios, principalmente de posgrado, no puede considerarse como un plan al que hay que ajustarse de manera estricta, sino que debe ser más flexible, que dé salida a los objetivos propuestos según las situaciones del entorno. Objetivo: mostrar algunos resultados de la vinculación del residente de Higiene y Epidemiología a actividades epidemiológicas emergentes en la actualidad. Método: se realizó un estudio descriptivo transversal en el Centro Provincial de Higiene, Epidemiología y Microbiología de Camagüey durante junio de (...) 2014. Se entrevistó a un universo de 32 profesionales. Las variables utilizadas fueron: utilidad de la vinculación extracurricular a programas y tareas de control epidemiológico, desarrollo práctico de los aspectos teóricos, vencimiento con calidad del diseño curricular de la residencia y si se consideró necesario o no interrumpir el plan de estudios ante eventos epidemiológicos de emergencia. Resultados: La mayoría de los especialistas consideró que la vinculación a actividades específicas le permitió vencer con calidad el plan de estudios, mientras que el mayor porcentaje de los residentes no lo estimó así. Ningún residente entrevistado estuvo de acuerdo con la interrupción del plan de estudios ante situaciones emergentes. Conclusiones: la vinculación del residente a actividades prácticas emergentes puede servir de incentivo para la graduación de un especialista con mayor competencia profesional, sin abandonar el diseño curricular establecido. Fundament: The study curriculum, especially of post grade, cannot be considered as a plan to which one has to be adjusted in a strict way, but to be more flexible, offering a way out to the proposed objectives according to the situations of the environment. Objective: to offer some results of the linking of the medical resident of Hygiene and Epidemiology to emergent epidemiological activities at the present time. Method: A cross-sectional descriptive study at the Provincial Center of Hygiene, Epidemiology and Microbiology during June 2014 was carried out. A universe of 32 professionals was interviewed. The variables used were: usefulness of the extracurricular linking to programs and tasks of epidemiological control, practical development of theoretical aspects, quality achievement of the curricular design of the medical residency, and if it was necessary or not to interrupt the study plan in emergent epidemiological events. Results: Most of the specialists considered the linking to emergent epidemiological activities allowed to finish with quality its study plan, while that the biggest percentage of the residents did not estimate it in the same way. None of the interviewed resident agreed with the interruption of the study plan in front of emergent situations. Conclusions: the linking of the medical resident to practical emergent activities can serve as incentive for the graduation of the specialists with better professional competence without abandoning the established curricular design. (shrink)

BackgroundHumor is a main ingredient of interpersonal relationships. Two sets of psychopathological traits known for their devastating impact on interpersonal relationships are psychopathy and narcissism. The current study was developed to provide a fine-grained analysis of the relationship between four humor styles and both psychopathic and narcissistic traits. Specifically, it addresses how humor styles relate to the three psychopathy subfactors and four subfactors of grandiose narcissism.MethodSelf-report measures in a non-clinical male sample N = 177.ResultsMultiple regression analyses revealed psychopathic and narcissistic (...) traits’ relation to using both benign and injurious humor. Subfactor analyses showed that aggressive and self-defeating humor were mostly associated with impulsivity and entitlement, while dominance levels actuated the use of humor to cope with stress. The cold-heartedness component of psychopathy proved to be particularly humorless, setting it aside as a distinctively disturbing psychopathic subfactor.Conclusions and implicationsHumor strongly colors the interpersonal style of both psychopathic and narcissistic personalities. Differential components of both personality types inform on the possible underlying motivations that drive the use of distinct styles of humor. This implies that psychopathic and narcissistic traits could potentially be lowered through the alternation of humor styles. (shrink)

El propósito del presente trabajo consiste en abordar la pregunta por la ontología de la química cuántica. Para ello nos concentraremos en el concepto de enlace químico desde la perspectiva de los dos enfoques a través de los cuales la ecuación de Schrödinger se aplica a los sistemas químicos moleculares: la teoría del enlace de valencia (EV) y la teoría del orbital molecular (OM). Sobre la base de la presentación de ambos enfoques y su comparación, señalaremos que, a pesar de (...) su denominación tradicional, no pueden considerarse estrictamente como teorías científicas, sino que se ajustan mejor a la noción de modelo; en particular, son modelos que incorporan conceptos y leyes tanto del ámbito de la mecánica cuántica como del de la química estructural. Estas consideraciones nos permitirán argumentar que la química cuántica no posee un referente ontológico autónomo, sino que se trata de un ámbito científico cuya vigencia descansa sobre su éxito práctico en el cálculo y la predicción. Finalmente, indicaremos de qué modo los enfoques EV y OM del enlace químico abren una nueva perspectiva respecto de la noción misma de modelo en ciencias empíricas. (shrink)

Tomando en cuenta las críticas más importantes a la teoría de los individuostransmundanos, así como algunos argumentos en relación con el esencialismo deorigen, este artículo trata el problema de la identidad de aquellos individuos a travésde mundos posibles. Proponemos la noción de mundo admisible como un tipo especial de modelo en Lógica Intensional, que, dentro de otro modelo, permite el mapeo de la historia e identidad de los individuos en diferentes mundos posibles. Esta propuesta sugiere una solución plausible para determinar (...) propiedades esenciales empíricamente relevantes ostentadas por los individuos transmundanos, un método eficaz para evaluar su identidad y, finalmente, una nueva perspectiva desde la cual reexaminar el clásico debate entre realismo y antirrealismo en la Filosofía del Lenguaje. Considering the most important criticisms to the theory of transworld individuals aswell as some problems related to origin essentialism, this article addresses the issue of the identity of those individuals across possible worlds. We propose the notion of admissible world as a special type of model in Intensional Logic, which, within another model, allows mapping the history and identity of individuals in different possible worlds. This view suggests a plausible solution for determining the empirically relevant essential properties of transworld individuals, a useful method to assess their identity, and, finally, a new way of reexamining the classical debate between realism and anti-realism in the Philosophy of Language. (shrink)

I argue that scientists should adopt a sexual orientation view that includes ‘internal’ sexual orientation markers such as desire, fantasies, and attraction, plus self-identification, and that these two markers should line up. By ‘internal’ markers, I mean inner states or processes of the agent. This can be contrasted with ‘external markers’, by which I mean, behaviours of the agent. I begin by critically reviewing four genetic studies of sexual orientation that are representative of the literature. I look at how each (...) of these studies deploy the concept of ‘sexual orientation’, and show a) that they are each using different notions, and b) that none of the notions are satisfactory. I argue that these accounts have a very limited amount of predictive and explanatory power. Following this, I outline what an account of sexual orientation that has more predictive and explanatory power might look like. I argue that this account will be one that includes internal markers and self-identification. (shrink)

El estudio del cuerpo humano mediante el apunte permite que el estudiante de Bellas Artes profundice en los complejos procesos perceptivos, cognitivos y procesuales propios del dibujo, ya que esta práctica favorece tanto el análisis del cuerpo humano, como la asimilación de estrategias para asumir la relación profunda que se establece entre el dibujante y aquello que observa, comprende y materializa en el propio dibujo. Por ello, esta ponencia es analiza los factores implicados en esta situación y ofrece diversas estrategias (...) que faciliten la adquisición de las competencias necesarias para ello tras implementar un programa de ejercicios para tal fin. (shrink)

As a rapidly growing field of study, social entrepreneurship is increasingly receiving attention from scholars and practitioners because social ventures have the potential to contribute to economic growth and social innovation. Surprisingly, the role of leadership in social venture growth has received very limited attention. One reason for this omission may be that entrepreneurship and leadership evolved as separate domains. Applying leadership theory to social ventures can help scholars and managers understand how social entrepreneurs can manage the environmental risks, dual (...) mission, and legitimacy issues of social ventures. Our goal for this conceptual paper is to describe how social entrepreneurs can align employees with the seemingly inconsistent goals of social and economic value creation to improve venture performance. We do so by concentrating on a leadership style applicable to their dual mission—servant leadership. Drawing from theoretical underpinnings and examples from single case studies, we offer a research framework and related propositions that delineate how servant leadership style affects social venture performance through the perception of work meaningfulness, well-being, and job engagement. We contribute to theory building by uncovering how social entrepreneurs can share their personal passions, values, and obligations with their employees and inspire them to meet their dual mission, paying attention to the context of social ventures and the attributes of the employees they attract. We also discuss theoretical and practical implications for social entrepreneurship and offer future research directions. (shrink)